Pias3 ELISA Kit for Mouse(Mus musculus) | EIAab.comPias3 ELISA Kit for Mouse(Mus musculus)

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Pias3 (Gene name),

E3 SUMO-protein ligase PIAS3 (Protein name ), PIAS3_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Pias3;

Protein name:

E3 SUMO-protein ligase PIAS3;

Alternative:

Protein inhibitor of activated STAT protein 3;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Binds SUMO1 and UBE2I. Interacts with AR, BCL11A, GFI1, HMGA2, IRF1, MITF, NCOA2, as well as with STAT3, after treatment with IL6, CNTF or OSM and with STAT5, after PRL stimulation. Interacts with PLAG1 (By similarity). Interacts with ZFHX3.

Function:

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.

Subcellular Location:

Nucleus speckle

Protein Attributes:

Sequence length:

628

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

628:

SSLREGHGGP | LPSGPSLTGC | RSDVISLD

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

O54714

UniGene:

Mm.1635

String:

O54714

Pfam:

PF14324

KEGG:

mmu:229615

Pfam:

PF02891

Uniprot:

O54714

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ELISA Kit for Mouse E3 SUMO-protein ligase PIAS3

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E1591m

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96T

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ELISA Kit for Mouse E3 SUMO-protein ligase PIAS3

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E1591h

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96T

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ELISA Kit for Mouse E3 SUMO-protein ligase PIAS3

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E1591r

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96T

CLIA Kit for Mouse E3 SUMO-protein ligase PIAS3

Cat.:

U1591r

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96T

CLIA Kit for Mouse E3 SUMO-protein ligase PIAS3

Cat.:

U1591m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse E3 SUMO-protein ligase PIAS3

Cat.:

U1591h

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96T

Polyclonal Antibody for Mouse E3 SUMO-protein ligase PIAS3

Cat.:

P1591Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse E3 SUMO-protein ligase PIAS3

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P1591Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse E3 SUMO-protein ligase PIAS3

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P1591Rb-m

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40ug/0.2ml

Monoclonal Antibody for Mouse E3 SUMO-protein ligase PIAS3

Protein for Mouse E3 SUMO-protein ligase PIAS3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
strain: C57BL/6J.
tissue: Embryo.
tissue: Thymus.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
strain: C57BL/6.
strain: FVB/N.
tissue: Mammary tumor.
tissue: Retina.
3.

"Specific inhibition of Stat3 signal transduction by PIAS3."
Chung C.D. , Liao J. , Liu B. , Rao X. , Jay P. , Berta P. , Shuai K.
Science278:1803-1805(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-628 (ISOFORM 3);SUBCELLULAR LOCATION;INTERACTION WITH STAT3
tissue: Thymus.
4.

Shuai K.
Submitted (2013-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
5.

"The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3."
Roedel B. , Tavassoli K. , Karsunky H. , Schmidt T. , Bachmann M. , Schaper F. , Heinrich P. , Shuai K. , Elsaesser H.-P. , Moeroey T.
EMBO J.19:5845-5855(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GFI1;FUNCTION;SUBCELLULAR LOCATION
6.

"Cloning and analysis of a murine Pias family member, Pias-gamma, in developing skin and neurons."
Sturm S. , Koch M. , White F.A.
J. Mol. Neurosci.14:107-121(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE;TISSUE SPECIFICITY
tissue: Brain.
7.

"ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation."
Kotaja N. , Aittomaeki S. , Silvennoinen O. , Palvimo J.J. , Jaenne O.A.
Mol. Endocrinol.14:1986-2000(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AR
8.

"Requirement for high mobility group protein HMGI-C interaction with STAT3 inhibitor PIAS3 in repression of alpha-subunit of epithelial Na+ channel (alpha-ENaC) transcription by Ras activation in salivary epithelial cells."
Zentner M.D. , Lin H.H. , Deng H.-T. , Kim K.-J. , Shih H.-M. , Ann D.K.
J. Biol. Chem.276:29805-29814(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HMGA2
9.

"PIAS3 (protein inhibitor of activated STAT-3) modulates the transcriptional activation mediated by the nuclear receptor coactivator TIF2."
Jimenez-Lara A.M. , Heine M.J.S. , Gronemeyer H.
FEBS Lett.526:142-146(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCOA2
10.

"PIAS3 induces SUMO-1 modification and transcriptional repression of IRF-1."
Nakagawa K. , Yokosawa H.
FEBS Lett.530:204-208(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IRF1; SUMO1 AND UBE2I;SUMOYLATION;MUTAGENESIS OF CYS-343
11.

"A new role for the STAT3 inhibitor, PIAS3: a repressor of microphthalmia transcription factor."
Levy C. , Nechushtan H. , Razin E.
J. Biol. Chem.277:1962-1966(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MITF;FUNCTION;SUBCELLULAR LOCATION
12.

"PIAS proteins modulate transcription factors by functioning as SUMO-1 ligases."
Kotaja N. , Karvonen U. , Jaenne O.A. , Palvimo J.J.
Mol. Cell. Biol.22:5222-5234(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SUMO1 AND UBE2I;SUBCELLULAR LOCATION
13.

"PIAS proteins promote SUMO-1 conjugation to STAT1."
Ungureanu D. , Vanhatupa S. , Kotaja N. , Yang J. , Aittomaeki S. , Jaenne O.A. , Palvimo J.J. , Silvennoinen O.
Blood102:3311-3313(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STAT1 SUMOYLATION
14.

"The 'PINIT' motif, of a newly identified conserved domain of the PIAS protein family, is essential for nuclear retention of PIAS3L."
Duval D. , Duval G. , Kedinger C. , Poch O. , Boeuf H.
FEBS Lett.554:111-118(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF THE PINIT MOTIF;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;MUTAGENESIS OF 19-LEU--LEU-23; 242-PRO--THR-244 AND 343-CYS--SER-348
15.

"BCL11A is a SUMOylated protein and recruits SUMO-conjugation enzymes in its nuclear body."
Kuwata T. , Nakamura T.
Genes Cells13:931-940(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BCL11A

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